Mouse Model of Genital Tract Infection Enhances Bacterial Survival in a Female A Gonococcal Efflux Pump System
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منابع مشابه
A gonococcal efflux pump system enhances bacterial survival in a female mouse model of genital tract infection.
Active efflux of antimicrobial substances is likely to be an important bacterial defense against inhibitory host factors inherent to different body sites. Two well-characterized multidrug resistance efflux systems (MtrCDE and FarAB-MtrE) exist in Neisseria gonorrhoeae, a bacterial pathogen of the human genital mucosae. In vitro studies suggest that the MtrCDE and FarAB-MtrE efflux systems prote...
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Historically, animal modeling of gonorrhea has been hampered by the exclusive adaptation of Neisseria gonorrhoeae to humans. Genital tract infection can be established in female mice that are treated with 17β-estradiol, however, and many features of experimental murine infection mimic human infection. Here we review the colonization kinetics and host response to experimental murine gonococcal i...
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To prevent the Gonococcal opthalmia neonatorum in many countries including Iran application of 1℅ tetracycline ophthalmic ointment is a common practice. To evaluate the prevalence of Gonococcal genital infection and the ophthalmic prophylaxis regimen we have tested specimens which were collected from the endocervix of 500 non – pregnant women attending a private and public gynecology clinic...
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The molecular mechanisms used by the gonococcus to initiate infection exhibit gender specificity. The clinical presentations of disease are also strikingly different upon comparison of gonococcal urethritis to gonococcal cervicitis. An intimate association occurs between the gonococcus and the urethral epithelium and is mediated by the asialoglycoprotein receptor. Gonococcal interaction with th...
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تاریخ انتشار 2003